Clone: C3
Background: Alpha-Feto Protein (AFP) is a protein produced by the fetus, which is excreted into the amniotic fluid and into the mother's bloodstream through the placenta. The amount of AFP, both in the maternalÕs blood and in the amniotic fluid, at particular periods during the pregnancy, may be associated with the presence of neural tube defects or chromosomal problems in the baby. AFP synthesis occurs in tissues including the gut, liver and fetal yolk sac. AFP expression may be seen in germ cell neoplasma and in liver carcinoma.
Positive Control: HepG2 cells
Immunogen: Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with purified human alpha-fetoprotein and mouse myeloma cells.
Purification Method: Protein A/G Chromatography
Concentration: See vial for concentration
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide
References: 1. Yazova AK; et al. 'Human alpha-fetoprotein epitopes as revealed by monoclonal antibodies.' Immunology Letters, 1990 Sep, 25(4):325-30.2. Sato, Y., et al. 'Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion.' Blood, 106, 756-763 (2005).
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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