Clone Number: 50
Immunogen: Recombinant protein corresponding to amino acids 701-808 located within the C-terminal of MALT1
Concentration: IgG 1 mg/ml
Format: Purified
Storage buffer: PBS with <0.1% sodium azide
Additional info: Mouse anti Human MALT1 antibody, clone 50 recognizes human mucosal-associated lymphoid tissue lymphoma translocation 1 (MALT1), also known as MALT lymphomaassociated translocation and paracaspase. MALT1 is an 824 amino acid ~93 kDa protein belonging to the peptidase C14B family containing a single death domain and two Ig-like CD-type domains. In normal lymphocytes, MALT1 plays an important role in antigen receptor-mediated lymphocyte activation. In T-cells, MALT1 is recruited by activated CARMA1, along with Bcl-10, to form a CARMA1-Bcl10-MALT1 (CBM) complex which is involved in the activation of NF-kappaB (Yang et al. 2013).
References: Ye H et al. J Pathol 2005; 205: 293-301/Coornaert B et al. Nat Immunol 2008; 9: 263-71/Rebeaud F et al. Nat Immunol 2008; 9: 272-81
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