Mouse anti-Isocitrate Dehydrogenenase 1 IDH1-R132S, clone SMab-1 (Monoclonal)

Clone Number: Smab

Immunogen: KLH-conjugated peptide human IDH1-R132S

Concentration: lot specific

Storage buffer: Tissue culture supernatant with sodium azide

Additional info: Isocitrate dehydrogenase 1 (IDH1) is a 46 kDa NADPdependent enzyme, which catalyzes the decarboxylation of isocitrate into α-ketoglutarate. IDH1 may also play a role in the prevention of oxidative damage, and the shuttling of proteins to peroxisomes. It is widely reported that mutations in IDH1 result in multiple forms of gliomas. The Arginine to Serine substitution at amino acid 132 is seen in gliomas, abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate.

References: Kaneko et al. 2011;406:608-613

• SKU: SANMON9988
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MON9988
• Package Unit: 1 ml
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Application: Immunohistochemistry (paraffin)
• Isotype: IgG1k
• Host: Mouse
• Conjugate: Unconjugated