Clone Number: L1C1
Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers
Concentration: n/a
Storage buffer: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Additional info: The antibody detects surface immunoglobulin on normal and neoplastic B-cells. In paraffin-embeddedtissue, anti-kappa exhibits strong staining of kappa-positive plasma cells and cells that have absorbedexogenous immunoglobulins. When dealing with B-cell neoplasms, the determination of light chainratios remains the centerpiece. Most B-cell lymphomas express either kappa or lambda light chains,whereas reactive proliferations display a mixture of kappa and lambda positive cells. If only a singlelight chain type is detected, a lymphoproliferative disorder exists. Monoclonality is determined by akappa-lambda ratio of greater than or equal to 3:1 or a lambda-kappa ratio greater than 2:1.
References: Hertel, BF, et al. Lab Invest 1977;36:12/Mendes S, Dreno B. Acta Derm Venereol. 2003;83(3):167-70/ Lee LA et al. Am J Otolaryngol. 2002 Sep-Oct;23(5):316-20
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