Clone Number: K2
Immunogen: Recombinant Ki-67 protein fragment close to C-terminus
Concentration: n/a
Storage buffer: Tissue culture supernatant with 15 mM sodium azide
Additional info: The Ki67 antigen is a nuclear protein which is expressed in all active parts of the cell cycle (G1, S, G2 and mitosis) but is absent in resting cells (G0). In contrast to many other cell cycle-associated proteins, the Ki67 antigen is consistently absent in quiescent cells and is not detectable during DNA repair processes. Thus, the presence of Ki67 antigen is strictly associated with the cell cycle and confined to the nucleus, suggesting an important role in the maintenance and/or regulation of the cell division cycle.
References: Gerdes J, et al. Int J Cancer 31:13-20 (1982)/Franklin WA, et al. Hum Pathol 16:1129-32 (1985)/Gerdes J, et al. J Immunol 133:1710-5 (1984)
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