Clone Number: 5B2
Immunogen: Recombinant prokaryotic fusion protein corresponding to approximately 100 amino acids which are present in the membrane-bound form of the mesothelin molecule.
Concentration: Greater than or equal to 40 mg/L
Storage buffer: Tissue culture supernatant with sodium azide
Additional info: Mesothelin is a glycosyl-phosphatidylinositol-linked (GPI) glycoprotein of 40kD present on the surface of mesothelial cells, mesotheliomas, epithelial ovarian cancers and some squamous cell carcinomas. It is synthesized as a 69 kD precursor which is enzymatically processed into an N-terminal secreted form of 30 kD and the GPI-linked membrane-bound form of 40 kD. The secreted form is identical to the megakaryocyte potentiating factor, but it is the GPI-linked membrane-bound form which has generated interest. Mesothelin is abundantly expressed in the kidney and in occasional epithelial cells of the trachea, tonsil and fallopian tube. The function of mesothelin is unclear but it may have a role in cellular adhesion. Mesothelin is reported to be abundant in the normal mesothelial cells from which malignant mesotheliomas and ovarian cystadenocarcinomas are derived.
References: Ordonez NG. American Journal of Surgical Pathology. 2003; 27(11):1418–1428/Ordonez NG. Modern Pathology. 2003; 16(3):192–197/Argani P et al. Clinical Cancer Research. 2001; 7(12):3862–3868
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