Clone Number: BraFB6
Immunogen: non-T, non-B human acute lymphoblastic leukemia REH6 cells
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: MHC class II molecules are encoded by polymorphic MHC genes and consist of a non-covalent complex of an α and β chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.
References: Babusikova O et al., Neoplasma 32(6): 657-62 (1985)/Polakova K et al., Neoplasma, 32(6): 641-8 (1985)/Horejsi V, et. al. Tissue Antigens, 32(1): 6-11 (1988)
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