Mouse anti-MHC II DP+DR (beta chain), clone Bra14 (Monoclonal)

Clone Number: Bra14

Immunogen: nuclei from pokeweed mitrogen-stimulated PBL

Concentration: 100 ug/ml

Storage buffer: PBS with 0.02% sodium azide

Additional info: MHC class II molecules are encoded by polymorphic MHC genes and consist of a non-covalent complex of an α and β chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.

References: Chorvath B et al. Neoplasma 34(4):417-425 (1987)/Horejsi V et al. Tissue Antigens 32(1):6-11 (1988)/Polakova K et al. Neoplasma 32(6):641-8 (1985)

• SKU: SANMON9871
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MON9871
• Green Labware: No
• Package Unit: 100 µg
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Application: Immunohistochemistry (frozen), Immunohistochemistry (paraffin), Flow Cytometry
• Isotype: IgG3-K
• Host: Mouse