Mouse anti-MHC II DRB, clone LN-3 (Monoclonal)

Clone Number: LN-3

Immunogen: nuclei from pokeweed mitrogen-stimulated PBL

Concentration: 100 ug/ml

Storage buffer: PBS with 0.02% sodium azide

Additional info: MHC class II molecules are encoded by polymorphic MHC genes and consist of a non-covalent complex of an α and β chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.

References: Marder, R.L. et al. Lab. Invest. 52: 497-504 (1985)/Andrade, R.E. et al. Human Pathology 19: 932-941 (1988)/Azumi N. et al. Human Pathology 19: 1376-1382 (1988)

• SKU: SANMON9873
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MON9873
• Green Labware: No
• Package Unit: 100 µg
• Quantity Unit: STK
• Reactivity: Human, Monkey (Primate)
• Clonality: Monoclonal
• Application: Immunohistochemistry (frozen), Immunohistochemistry (paraffin), Flow Cytometry
• Isotype: IgG2b-k
• Host: Mouse