Clone Number: 34CA5
Immunogen: Prokaryotic recombinant protein corresponding to 111 amino acids of the N-terminal region of the MITF-M molecule
Concentration: n/a
Storage buffer: Tissue culture supernatant with 15mM Sodium azide
Additional info: Microphthalmia transcription factor (MITF) gene product, a nuclear transcription factor of the basic-helix-loop-helix type, is thought to play a role in the regulation of genes encoding the enzymes necessary for melanogenesis. These include tyrosinase, TRP-1 and TRP-2. MITF is critical for the embryonic development and postnatal viability of melanocytes. The melanocyte-specific isoform of microphthalmia transcription factor MITF-M, is reported to be expressed in normal and malignant melanocytes. The other isoforms, MITF-A, MITF-C and MITF-H, differ structurally at the N-terminus from MITF-M.
References: Fang D and Setaluri V. Biochem. and Biophys. Research Comm. 256 (3): 657–663 (1999)/King R et al. American Journal of Pathology. 155 (3): 731–738 (1999)/Amae S et al. Biochem.and Biophys.Research Comm. 247: 710–715 (1998)
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