Mouse anti-MSH6, clone 44

Clone Number: 44

Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers

Concentration: n/a

Storage buffer: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide

Additional info: MSH6 is a mismatch repair gene which is deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition known as Hereditary Non-Polyposis Colon Cancer (HNPCC). The anti-MSH6 antibody is useful in screening patients and families for this condition. Colon cancers that are microsatellite unstable have a better prognosis than their microsatellite stable counterparts.

References: Lagerstedt Robinson K, et al. J Natl Cancer Inst. 2007 Feb 21;99(4): 291-9/Niessen RC et al. Gut 2006 Dec;55(12):1781-8/Lawes DA et al. Br J Cancer. 2005 Aug 22; 93(4):472-7

• SKU: SANMON-RTU1151
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MON-RTU1151
• Green Labware: No
• Package Unit: 7 ml
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Application: Immunohistochemistry (paraffin)
• Isotype: IgG1
• Host: Mouse