Clone Number: 2-12M1
Immunogen: mucin isolated from an ovarian cyst fluid
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: 2-12M1 recognizes the peptide core of gastric mucin M1/MUC5AC, and more specifically with the ‘c’ epitope amongst the a, b, c, d, e, f, g, and h protein core epitopes defined by Bara for M1. 2-12M1 and 45M1 both specifically react with epitopes located in the Cterminal cysteine rich part of the peptide core of gastric mucin (MUC5AC). MUC5AC is present in primary ovarian mucinous cancer and gastric cancer, but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. AntiMUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.
References: Bara, J. et al., Cancer Res.46: 3983-3989 (1986)/Bara, J. et al., Biochem. J. 254: 185-193 (1988)/Bara, J. et al., Int. J. Cancer 47: 304-310 (1991)
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