Mouse anti-MVP/LRP, clone 1027 (Monoclonal)

Mouse anti-MVP/LRP, clone 1027 (Monoclonal)
SKU
SANMON9045
Packaging Unit
100 µg
Manufacturer
Sanbio / Monosan

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Clone Number: 1027

Immunogen: affinity purified nuclear extract proteins

Concentration: 100 ug/ml

Storage buffer: PBS with 0.02% sodium azide

Additional info: 1027 Is specific for the major vault protein, a 104-kDa highly conserved protein interacting with estrogen receptor. It is one of a series of four mAbs which recognize different epitopes of the protein. Major vault proteins have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.

References: Abbondanza, C. et al, J. Cell Biol. 141, 1301-1310 (1998)/Den Boer, M.L. et al. Blood 91, 2092-2098 (1998)
More Information
SKU SANMON9045
Manufacturer Sanbio / Monosan
Manufacturer SKU MON9045
Green Labware No
Package Unit 100 µg
Quantity Unit STK
Reactivity Human
Clonality Monoclonal
Application Immunofluorescence, Immunohistochemistry (frozen), Western Blotting
Isotype IgM
Host Mouse
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