Mouse anti-Oct-3/4, clone N1NK (monoclonal)

Clone Number: N1NK

Immunogen: Prokaryotic recombinant protein corresponding to 147 amino acids of the N-terminus of the human Oct-3/4 molecule.

Concentration: Greater than or equal to 69 mg/L

Storage buffer: Tissue culture supernatant with sodium azide

Additional info: Oct-3/4 is a member of the POU homeodomain family of transcription factors, which is expressed by embryonic stem cells and germ cells. A critical amount of Oct-3/4 is required to maintain stem cell self replication. Down regulation of Oct-3/4 levels are associated with loss of pluripotency. Oct-3/4 has been proposed as a useful marker for germ cell tumors which exhibit features of pluripotentiality, including seminoma/dysgerminoma/germinoma and embryonal carcinoma, and establishing a germ cell origin for some metastatic tumors of uncertain primary origin.

References: Del Sordo R et al. Histology and histopathology. 2014; 29(1):101-106/Miettinen M et al. American Journal of Surgical Pathology. 2014; 38(3):410-420/Paine SML et al. Neuropathology and applied neurobiology. 2014; 40:544-550

• SKU: SANMONX11104
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MONX11104
• Package Unit: 1 ml
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Application: Immunohistochemistry (paraffin)
• Isotype: IgG1
• Host: Mouse
• Conjugate: Unconjugated