Mouse anti-p53, clone Bp53-12 (Monoclonal)

Clone Number: Bp53-12

Immunogen: recombinant human p53 protein

Concentration: 100 ug/ml

Storage buffer: PBS with 0.02% sodium azide

Additional info: Bp53-12 reacts with an N-terminal epitope (aa 16-25) of both wild-type and mutated p53. This epitope is revealed in tissue sections only after formalin fixation. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution.

References: Bártek J. et al, J Pathol. 169(1):27-34 (1993)/Vogelstein and Kinzler, Cell 70: 523-526, (1992)/Hollstein et al, Science 253: 49-53: (1991)

• SKU: SANMON9915
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MON9915
• Package Unit: 100 µg
• Quantity Unit: STK
• Reactivity: Human, Monkey (Primate), Dog (Canine), Hamster, Chicken
• Clonality: Monoclonal
• Application: Immunofluorescence, Immunohistochemistry (paraffin), Western Blotting, Flow Cytometry
• Isotype: IgG2a-A
• Host: Mouse
• Conjugate: Unconjugated