Mouse anti-p53 Monoclonal Antibody, Purified (DO-1)

Stock Concentration: 1000 µg/ml

Conjugate Type: Unconjugated

Buffer: Tris-buffered Saline containing 0.09% Sodium Azide, BSA-Free

Shelf Life: 1 year from date of receipt

Protein ID: NP_000537.3

Uniprot ID: P04637

Background: p53 is a tumor suppressor protein that is mutated or inactivated in over 50% of human cancers. Loss of function defects in p53 are the cause of the autosomal dominant familial cancer syndrome, Li-Fraumeni syndrome (LFS) that is characterized by the development of a diverse set of malignancies at very early ages. At the cellular level p53 is involved in the negative regulation of cell the cycle via its transactivational control of genes required for cell cycle progression. Depending on the physiological circumstance, p53 can promote growth arrest or apoptosis.

Immunogen: Recombinant Full length protein corresponding to Human p53 (N terminal). epitope is within aa 20-25

• SKU: BEYA500-015ACF
• Manufacturer: Bethyl Laboratories
• Manufacturer SKU: A500-015ACF
• Green Labware: No
• Package Unit: 100 µl
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Application: Immunoprecipitation, Western Blotting, Flow Cytometry, Immunohistochemistry
• Isotype: Whole IgG
• Human Gene ID: 7157
• Host: Mouse