Mouse anti-PD1, clone NAT105

Clone Number: NAT105

Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers

Concentration: n/a

Storage buffer: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide

Additional info: Programmed death-1 (PD-1), also known as CD279, is a type-I transmembrane protein expressed on T-cells, B-cells, and monocytes during activation.1-2 PD-1 and its ligands (PD-L1 and PD-L2) function as an immune checkpoint pathway by regulating T-cell activation and autoimmunity.2 PD-1 labels follicular helper T-cells and is therefore a useful marker for angioimmunoblastic T-cell lymphoma.3-4

References: Bolstad AI, et al. Arthritis Rheum. 2003 Jan;48(1):174-85/Dorfman DM, et al. Am J Surg Pathol. 2006 Jul;30(7):802-10/Hamanishi J, et al. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3360-5

• SKU: SANMON-RTU1177
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MON-RTU1177
• Green Labware: No
• Package Unit: 7 ml
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Application: Immunohistochemistry (paraffin)
• Isotype: IgG1
• Host: Mouse