Mouse anti-Retinoblastoma Gene Protein, clone 13A10 (monoclonal)

Clone Number: 13A10

Immunogen: Recombinant prokaryotic protein corresponding to a portion of the N-terminal region of the retinoblastoma gene product.

Concentration: n/a

Storage buffer: Tissue culture supernatant with 15mM sodium azide

Additional info: Retinoblastoma (Rb) is a rare tumor of the retina associated with mutations of chromosome 13. The nuclear phosphoprotein encoded by the Rb tumor suppressor gene is present in many cells and may indirectly regulate cell growth by activating the transcription factor ATF-2. Activation of ATF-2 initiates expression of TGF-beta2, which in turn inhibits transcription of genes affecting cell growth. Bilateral mutation of the Rb gene may potentially play a role in the development of a number of malignant tumors.

References: Jares P et al. Journal of Pathology. 182: 160-166 (1997)/Karpeh MS et al. British Journal of Cancer. 72: 986-991 (1995)/Stefanini M et al. Nature. 216: 173-174 (1967)

• SKU: SANMONX10208
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MONX10208
• Green Labware: No
• Package Unit: 1 ml
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Application: Immunohistochemistry (paraffin)
• Isotype: IgG1
• Host: Mouse