Clone Number: AC25
Immunogen: Prokaryotic recombinant protein containing 105 amino acids corresponding to a portion of the N-terminus of the human thyroid peroxidase molecule.
Concentration: Greater than or equal to 10.8 mg/L
Storage buffer: Tissue culture supernatant with sodium azide
Additional info: Thyroid peroxidase gene expression is under the regulation of thyroid stimulating hormone. In normal thyroid, expression of thyroid peroxidase (TPO) described immunohistochemically is reported to produce a diffuse, fine, granular cytoplasmic stain in all follicular cells. Some studies have shown qualitative, as well as quantitative differences in thyroid peroxidase expression in thyroid cancer compared to normal tissue.
References: Kimura S et al. Proceedings of the National Academy of Science USA 84: 5555-5559 (1987)/De Micco C et al. Cancer 67(12): 3036–3041 (1991)/Czarnocka B et al. Breast Journal Cancer 85(6): 875–880 (2001)
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