Mouse anti-Wilms' Tumor, clone WT49 (monoclonal)

Clone Number: WT49

Immunogen: A prokaryotic recombinant protein containing 1–181 amino acids of the N-terminal of the Wilms’ Tumor protein.

Concentration: Greater than or equal to 44 mg/L

Storage buffer: Tissue culture supernatant with sodium azide

Additional info: Wilms' tumor protein (WT1) has a role in transcriptional regulation and is expressed in the kidney and a subset of hematopoietic cells. Alteration of transcription factor function is a common mechanism in oncogenesis. The WT1 protein contains a DNA binding domain and any deletions or point mutations of the WT1 gene which destroy this activity result in the development of the childhood nephroblastoma Wilms' tumor and Denys-Drash syndrome. The description of WT1 involvement in nephroblastoma is not clear.

References: Omeroglu A and Omeroglu G. Arch Pathol Lab Med. 2003; 127:e347-e348/Lee SB and Haber DA. Experimental Cell Research. 2001; 264:74-99

• SKU: SANMONX11064
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MONX11064
• Package Unit: 1 ml
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Application: Immunohistochemistry (paraffin)
• Isotype: IgG1
• Host: Mouse
• Conjugate: Unconjugated