Abbreviation: MS4A2
Target Synonym: MS4A2;APY;ATOPY;FCER1B;FCERI;IGEL;IGER;IGHER;MS4A1
Conjugation: Unconjugated
UNIProt ID: Q01362
Background: The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation.
Concentration: 1mg/mL
Immunogen: A synthetic peptide of human MS4A2
Dilution: WB 1:500-1:2000
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