Product Type: Blocker
CAS No.: 541-91-3
MolecularFormula: C16H30O
Molecular Weight: 238,4
Source: Synthetic
Purity: >98% (TLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (35 mg/ml); or Ethanol (35 mg/ml)
Appearance: Colorless oil
PubChem CID: 10947
Scientific Background: Muscone is a macrocyclic ketone found naturally in a glandular secretion of the musk deer which acts at human odorant receptor OR5AN1 and is used in perfumes(1). It suppresses inflammatory responses and neuronal damage in various models including a rat model of cervical spondylotic myelopathy (2) and relieves inflammatory pain acting via the NOX4/JAK2-STAT3 and NLRP3 inflammasome pathway (3). In the cardiovascular system it alleviates myocardial ischemia-reperfusion injury (4) and improves cardiac function in mice after myocardial infarction (5) via enhancement of angiogenesis (6).
References: 1. Ahmed L., et al. (2018) Proc. Acad. Natl. Sci. USA. 115:E39502. Zhou L.Y., et al. (2020) J. Neurochem. 155:1543. Yu S., et al. (2020) Int. Immunopharmacol. 82:1063554. Wei C.J., et al. (2021) J. Biol. Regul. Homeost. Agents. 35:855. Du Y., et al. (2018) Am. J. Transl. Res. 10:42356. Du Y., et al. (2018) Med. Sci. Monit. 24:8870
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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