Application Note: WB: 1:1000. ICC/IF: 1:10-1:50. FACS: 1:10-1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 60
Form: Liquid
Buffer (with preservative): PBS, 0.09% Sodium azide.
Concentration: Batch dependent (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]
Uniprot ID: Q9UIF7
Antigen Species: Human
Immunogen: KLH conjugated synthetic peptide between 341-367 amino acids from the Central region of human MUTYH.
Purification: Purified by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Conjugation: Unconjugated
Full Name: mutY DNA glycosylase
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