Myostatin

Myostatin
SKU
CGSGFH22-500
Packaging Unit
500 μg
Manufacturer
Cell Guidance Systems

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Product Description: Myostatin, also known as GDF-8, a conserved member of the TGF-β superfamily, is an essential regulator of skeletal muscle mass and cardiac muscle development and function. Myostatin is a secreted protein that negatively regulates skeletal muscle growth by determining muscle fiber number and size. Myostatin binds one of the two activin type II receptors (ACTRIIA, ACTRIIB) to activate SMAD signaling. Myostatin also activates MAPK signaling through TAK1-MKK6 and Ras pathways. Inhibition of myostatin increases muscle mass in a number of human disease animal models, such as muscular dystrophy.

Growth Factor AA Sequence: DFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS
More Information
SKU CGSGFH22-500
Manufacturer Cell Guidance Systems
Manufacturer SKU GFH22-500
Package Unit 500 μg
Quantity Unit STK
Reactivity Human
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