N-Butanoyl-L-homoserine lactone, CAS 67605-85-0

Product Description: N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm[1]. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa[2][3].

Applications: COVID-19-immunoregulation

Formula: C8H13NO3

References: [1]Keith Alan Charlton, et al. Methods for the Treatment of an Infectious Bacterial Disease with an Anti-Lactone or Lactone Derived Signal Molecules Antibody. US20130045208A1/[2]Zhao M, et al. C4-HSL aptamers for blocking qurom sensing and inhibiting biofilm formation in Pseudomonas aeruginosa and its structure prediction and analysis. PLoS One. 2019 Feb 19;14(2):e0212041./[3]Feng Sun, et al. Advance of the diversity of bacterial quorum sensing and quorum quenching. National Natural Science Foundation of China. Published online 9 October 2018.

CAS Number: 67605-85-0

Molecular Weight: 171.196

Compound Purity: 98.0

Research Area: Infection; Inflammation/Immunology

Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : 20 mg/mL (ultrasonic;warming;heat to 60°C)

Target: ADC Linker;Bacterial

• SKU: MEXHY-114816-5G
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-114816-5G
• Package Unit: 5 g
• Quantity Unit: STK