N3-C3-NHS ester, CAS 943858-70-6

Product Description: N3-C3-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-C3-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Applications: Cancer-programmed cell death

Formula: C8H10N4O4

References: [1]Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. J Med Chem. 2017 Dec 14;60(23):9490-9507.

CAS Number: 943858-70-6

Molecular Weight: 226.19

Compound Purity: 99.46

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: ADC Linker

• SKU: MEXHY-126521-100
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-126521-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK