N3-C4-NHS ester, CAS 478801-48-8

Product Description: N3-C4-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-C4-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Applications: Cancer-programmed cell death

Formula: C9H12N4O4

References: [1]Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. J Med Chem. 2017 Dec 14;60(23):9490-9507.

CAS Number: 478801-48-8

Molecular Weight: 240.22

Compound Purity: 99.34

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ADC Linker

• SKU: MEXHY-126522-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-126522-10
• Package Unit: 10 mg
• Quantity Unit: STK