Product Description: NAMPT inhibitor-linker 2 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <7 pM and 40 pM, respectively.
Applications: Cancer-programmed cell death
Formula: C34H33FN6O5
References: [1]Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28;9(8):838-842.
CAS Number: 2241014-82-2
Molecular Weight: 624.66
Compound Purity: 98.11
Research Area: Cancer
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: Drug-Linker Conjugates for ADC;NAMPT