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Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Background: NEK6 is a protein kinase in the NIMA-related serine/threonine kinase family that plays a role in mitotic cell cycle progression. Overexpression of NEK6 has been linked to many human diseases including liver, breast, lung, stomach, colon, larynx, ovary and prostate cancer, making NEK6 an attractive target for anti-cancer therapeutics. Inhibition of NEK6 has been shown to induce cell death and premature senescence.
Description: The NEK6 Kinase Assay Kit is designed to measure NEK6 kinase activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent.
Storage Stability: Up to 6 months when stored as recommended.
Supplied As: The NEK6 Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant NEK6 enzyme, MBP substrate, ATP and kinase assay buffer for 100 enzyme reactions.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: Yin, M.-J., et al. 2003. "The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis." J. Biol. Chem. 278(52): 52454-52460.
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