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Applications: Study enzyme kinetics and screen small molecule inhibitors for drug discovery and high throughput screening (HTS) applications.
Background: The NIMA-related Kinase (NEK) family are serine/threonine kinases, also known as mitotic kinases. NEK7 is activated via phosphorylation at Ser-195, and is involved in microtubule nucleation, mitotic spindle formation and cytokinesis. Overexpression or abnormal activity of NEK7 can lead to uncontrolled cell division and growth, a hallmark of cancer. NEK7 is also involved in Muckle-Wells Syndrome and Cinca Syndrome. Protein kinase inhibitors have been extensively studied as potential therapeutical approaches for cancer, with attention starting to focus on NEK7 specific inhibitors as potential neoplastic drugs.
Description: The NIMA-related Kinase 7 (NEK7) Kinase Assay Kit is designed to measure NEK7 serine/threonine kinase activity for screening and profiling applications using ADP-Glo™ as a detection reagent.
Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.
Supplied As: The assay kit comes in a convenient 96-well format, with enough purified recombinant NEK7 kinase, kinase substrate, ATP, and kinase assay buffer for 100 enzyme reactions.
Uniprot: Q8TDX7
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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