Abbreviation: NRAS
Target Synonym: NRAS;ALPS4;CMNS;N-ras;NCMS;NRAS1;NS6
Conjugation: Unconjugated
UNIProt ID: P01111
Background: This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.
Concentration: 1mg/mL
Immunogen: A synthetic peptide of human NRAS
Dilution: WB 1:500-1:2000,IF 1:50-1:200