Abbreviation: OGG1
Target Synonym: OGG1;HMMH;HOGG1;MUTM;OGH1
Conjugation: Unconjugated
UNIProt ID: O15527
Background: This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human OGG1
Dilution: WB 1:200-1:1000
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