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Background: P21, also known as cyclin dependent kinase inhibitor 1A or CDKN1A, inhibits cyclin/CDK (cyclin dependent kinase) complexes and thus inhibits DNA repair and cell cycle progression. P21 also interacts with PCNA (proliferating cell nuclear antigen) and has been reported to inhibit apoptosis. It is activated by p53 and negatively regulated by the E3 ubiquitin ligase complex SCF (Skp, cullin, F-box containing complex). Expression of cytosolic p21 has been linked to cancer, and can be used as a prognostic tool. Studies focusing on p21 will continue to advance the cancer therapy field.
Description: Recombinant human p21 transcript 1, full-length encompassing amino acids 2-164 (end). This construct has an N-terminal GST-tag. This protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_000389
Purity: ≥85%
Storage Stability: At least 6 months at -80°C.
Tags: N-Terminal GST Tag
Uniprot: P38936
Warnings: Avoid freeze/thaw cycle
Biosafety Level: Not applicable (BSL-1)
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