Clone Name: GT1181
Application Note: WB: 1:500 - 1:2000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 113
Specificity/Sensitivity: This antibody is specific for cleaved PARP (~25kDa). It does not recognize full-length (~116kDa) and the large fragment (~89 kDa).
Form: Liquid
Buffer (with preservative): PBS, 50% Glycerol, 0.02% Sodium azide.
Concentration: Batch dependent (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
Uniprot ID: P09874
Antigen Species: Human
Immunogen: A synthesized peptide derived from human Cleaved PARP.
Conjugation: Unconjugated
Full Name: poly(ADP-ribose) polymerase 1
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