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Encompassing Amino Acids: 2-350 (end)
Applications: Useful for protein binding assays, screening inhibitors, and selectivity profiling.
Background: Transcriptional repressor that modulates the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.
Description: Human Polycomb group RING finger protein 6 (PCGF6), GenBank Accession No. NM_001011663, a.a. 2-350 (end), with N-terminal GST-tag, MW=65.7 kDa, expressed in a baculovirus expression system.
Format: Aqueous buffer solution
Formulation: 40 mM Tris. pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, and 20% glycerol.
Genbank: NM_001011663.1
Host Cell Line: Sf9 cells
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal GST-tag
Uniprot: Q9BYE7
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Junco SE, et al.,Structure. 2013;
21(4):665-71.
2. Kajiume T, et al., Exp Hematol.
2012; 40(9):751-760.
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