PDE1-IN-9, CAS 2982945-41-3

Product Description: PDE1-IN-9 (Compound 7a) is a selective inhibitor for phosphodiesterase 1 (PDE1), that inhibits PDE1C with an IC50 of 11 nM. PDE1-IN-9 reduces mRNA expression of IL-1β, IL-6, TNF-α and iNOS, inhibits the production of nitric oxide (NO) and reactive oxygen species (ROS). PDE1-IN-9 exhibits good metabolic stability in rat liver microsomes[1].

Formula: C28H31N3O2

References: [1]Zhou Q, et al., Design, synthesis, and evaluation of quinolin-2(1H)-ones as PDE1 inhibitors for the treatment of inflammatory bowel disease. Bioorg Chem. 2024 Nov 19;154:107979.

CAS Number: 2982945-41-3

Molecular Weight: 441.56

Research Area: Inflammation/Immunology

Target: NO Synthase;Phosphodiesterase (PDE);Reactive Oxygen Species

• SKU: MEXHY-169402-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-169402-0
• Package Unit: Get quote
• Quantity Unit: STK