Product Type: Inhibitor
CAS No.: 357166-29-1
MolecularFormula: C20H19N5Na2O6 [7H2O]
Molecular Weight: 597,5
Source: Synthetic
Purity: >98% (TLC, HPLC); NMR (Conforms)
Solubility: May be dissolved in Water (100 mg/ml)
Appearance: White powder
PubChem CID: 135564751
Scientific Background: Pemetrexed is a folate antimetabolite that inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase, three enzymes used in purine and pyrimidine synthesis. It is an antifolate cancer drug.
References: 1. McLeod H.L., et al. (2000) Clin Can Research: Clin Trials. 6(7): 2677-2684.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.