Clone Name: HL2204
Light Chain: Kappa
Application Note: WB: 1:1000-1:10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 54
Specificity/Sensitivity: This antibody is specific for human PFKFB4 protein, and it does not cross react with human PFKFB1, PFKFB2, and PFKFB3 protein.
Form: Liquid
Buffer (with preservative): PBS, no preservative.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Uniprot ID: Q16877
Antigen Species: Human
Immunogen: Recombinant fragment of human PFKFB4.
Purification: Affinity purified by Protein A.
Conjugation: Unconjugated
Full Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
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