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Encompassing Amino Acids: 1146 - 1287
Applications: Useful for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.
Background: PHIP is a bromodomain-containing protein that binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1 ), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival. It stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation.
Description: Human bromodomain pleckstrin homology domain interacting protein (PHIP), also known as IRS-1 PH Domain-Binding Protein, WDR11, and BRWD2, GenBank Accession No. NM_017934, a.a. 1146 - 1287 corresponding to bromodomain 1 , with N-terminal GST-tag, MW = 43 kDa, expressed in an E. coli cell expression system.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl, pH 8, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, and 20% glycerol.
Genbank: NM_017934
Storage Stability: Store at -80°C. Stable for >6 months when stored as directed.
Tags: N-terminal GST-tag
Uniprot: Q8WWQ0
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. De Semir, D., et al., Proc. Natl. Acad. Sci. USA. 2012 May 1;109(18):7067-72.
2. Farhang-Fallah, J., et al., J. Biol. Chem. 2000 Dec 22;275(51):40492-7.
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