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Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Background: PI3Ks (Phosphatidylinositol 3-kinases) are lipid kinases that phosphorylate PIP2 (phosphatidylinositol 4,5-bisphosphate) to produce PIP3 (phosphatidylinositol 3,4,5-trisphosphate), which plays important roles in fundamental cellular activities such as cell growth, survival, migration, and metabolism. In human cancers, gain-of-function mutations of PI3Ks are found frequently, suggesting that PI3Ks are closely involved in tumorigenesis and that PI3K targeting inhibitors may be promising anticancer drug candidates.
Contraindications: Avoid >0.5% DMSO. Higher DMSO levels can significantly decrease the enzyme activity.
Description: The PI3Kβ (p110β/p85α) Assay Kit is designed to measure PI3Kβ activity for screening and profiling applications, using ADP-Glo® Kinase Assay as a detection reagent.
Storage Stability: Up to 6 months when stored as recommended.
Supplied As: The PI3Kβ (p110β/p85α) Assay Kit comes in a convenient 96-well format, with enough purified recombinant PI3Kβ enzyme, PI3K lipid substrate, ATP and kinase assay buffer for 100 enzyme reactions.
Biosafety Level: Not applicable (BSL-1)
References: Zhao W., et al. Acta Pharmaceutica Sinica B, 7(1): 27-37 (2017)
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