Target: Piccolo.
Conjugate: ATTO 594.
Product Type: Polyclonal.
Immunogen: Recombinant Full length Protein, BC001304.1.
Swiss-Prot: Q9Y6V0.
Purification: Protein A Purified.
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide.
Concentration: 1 mg/ml.
Specificity: Detects ~550kDa. No cross-reactivity to Bassoon.
Cellular Localization: Cell Junction, Synapse.
Scientific Background: Piccolo, also referred to as Aczonin, is a large protein which consists of an N-terminal Zn2+ finger, several piccolo-bassoon homology domains and C-terminal PDZ and C2 domains (1, 2). In general it is found together with bassoon, a related huge multi-domain protein of the CAZ (cytoskeletal matric assembled at active zones) (3). Piccolo is a scaffolding protein for proteins involved in endo- and exocytosis of synaptic vesicles. Piccolo has also been shown to interfere with clathrin medicated endocytosis by binding to the F-actin and dynamin binding protein Abp1 (2).
References: 1. Gerber S.H., Garcia J., Rizo J., Sudhof T.C. (2001) EMBO J. 20(7): 1605-1619.2. Wang X., et al. (1999) J Cell Biol. 147(1): 151-162.3. Dresbach T., et al. (2006) J Biol Chem. 281(9):6038-6047.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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