Clone Name: GT1192
Application Note: WB: 1:500 - 1:2000. IHC-P: 1:50 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 45
Form: Liquid
Buffer (with preservative): PBS, 50% Glycerol, 0.02% Sodium azide.
Concentration: Batch dependent (Please refer to the vial label for the specific concentration.)
Background: The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]
Uniprot ID: P11309
Antigen Species: Human
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 110-150 of human PIM1.
Purification: Purified by affinity chromatography
Conjugation: Unconjugated
Full Name: Pim-1 proto-oncogene, serine/threonine kinase
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