PLN Polyclonal Antibody, Rabbit

Abbreviation: PLN

Target Synonym: CMD1P;CMH18;PLB;PLN

Conjugation: Unconjugated

UNIProt ID: P26678

Background: The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.

Concentration: 1mg/mL

Immunogen: A synthetic peptide of human PLN

Dilution: WB 1:500-1:2000

• SKU: ELSE-AB-93218-200
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-E-AB-93218-200
• Green Labware: No
• Package Unit: 200 µl
• Quantity Unit: STK
• Reactivity: Mouse (Murine), Rat (Rattus)
• Clonality: Polyclonal
• Application: Western Blotting
• Isotype: IgG
• Host: Rabbit