Abbreviation: PMP70/ABCD3
Target Synonym: ABC43;CBAS5;PMP70;PXMP1;ZWS2;ABCD3
Conjugation: Unconjugated
UNIProt ID: P28288
Background: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human PMP70/ABCD3
Dilution: WB 1:500-1:2000,IHC 1:50-1:200,IF 1:50-1:200
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