Clone Name: 5H10
Light Chain: Kappa
Application Note: WB: 1:500-1:2000. ICC/IF: 1:200-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 78
Form: Liquid
Buffer (with preservative): Filter-sterilized PBS, 50% Glycerol, no preservative.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Uniprot ID: Q9Y253
Antigen Species: Human
Immunogen: Human recombinant full-size Pol eta tagged with His6
Purification: Purified by salting-out and ion-exchange chromatography
Conjugation: Unconjugated
Full Name: DNA polymerase eta
English
Deutsch
