Immunogen: Synthetic human VIP (Peninsula, #7161)
Concentration: n/a
Storage buffer: Lyophilized; reconstitute in 100 µl dist. water
Additional info: VIP is localized in nerve fibers of the central and peripheral nervous system, and is probably acting as a neurotransmitter. Smooth muscle relaxation, vasodilation and secretion from exocrine glands are some of the effects of VIP. The Verner-Morrison or Watery Diarrhea Hypokaliemia and Achlorhydria (WDHA) syndrome is a characteristic clinical syndrome associated with overproduction of VIP from endocrine tumors. These VIP-producing tumors are usually neuroblastomas of endocrine tumors in the pancreas.
Absorption with 10-100 ug immunogen per ml diluted antiserum abolishes the staining, while PHI does not.
Positive control: Stefanini-fixed frozen sections of rat intestine.
References: Messell, T. et al. Regul. Pept.1992; 38: 179–198/Karila, P. et al. Cell 1997;287:525-533
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