Immunogen: Isolated from human placenta
Concentration: n/a
Storage buffer: Contains 0.09% sodium azide
Additional info: The antibody is reactive with collagen type IV of basement membranes, and shows a homogeneous staining pattern in all tissues. As neoplastic cells of invasive carcinomas often lack a continuous basement membrane, the antiserum is useful to distinguish between non-invasive and invasive lesions. Additionally, it can be used for the differentiation of bullous lesions in dermatopathology. In immunohistochemistry no cross-reactivity with other collagens at optimal dilutions. In immunoblotting, a slight cross-reactivity with collagen type V is observed.Positive control: Skin, kidney.
References: Chandana E et al. BMC Dev Biol 2010;10:84/Zahner et al. Oncotarget 2017;8:52560-52570/Oh J et al. Oncogene 2004;23:5041-5048
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