Target: PPM1H
Conjugate: HRP
Product Type: Monoclonal
Clone Number: 10D2
Immunogen: Recombinant Human PPM1H Protein
Swiss-Prot: Q9ULR3
Purification: Protein G Purified
Storage Buffer: PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1mg/ml
Specificity: Detects ~55kDa
Cellular Localization: Intracellular
Tissue Specificity: Parathyroid gland
Scientific Background: PPM1H is an independent prognostic biomarker of non-small cell lung cancer (1). PPM1H acts as a key modulator of LRRK2 signaling by controlling dephosphorylation of Rab proteins (2). PPM1H is also suggested to be a gatekeeper to prevent excessive bone morphogenetic protein (BMP) signalling through dephosphorylation (3).
References: 1. Zhang W.Q., et al. (2021) Neoplasma. 68(5): 917-923. 2. Berndsen K., et al. (2019) 8:e50416. 3.Shen T., et al. (2014) Cell Res. 24(6): 727-741.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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