PQR620, CAS 1927857-56-4

Formulation: A solid

Formal Name: 5-[4,6-bis(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]-4-(difluoromethyl)-2-pyridinamine

Purity: ≥98%

Formula Markup: C21H25F2N7O2

Formula Weight: 445,5

Shelf life (days): 1460

CAS Number: 1927857-56-4

Notes: PQR620 is an inhibitor of mTOR (Ki = 10.8 nM).{49937} It is selective for mTOR over PI3K p110α (Ki = 4.2 µM) and a panel of 456 other kinases at 10 µM. PQR620 has antiproliferative activity against a panel of 66 cancer cell lines (mean IC50 = 919 nM). It induces cell cycle arrest at the G1 phase in A2058 melanoma and SKOV3 ovarian cancer cells when used at a concentration of 5 µM. In vivo, PQR620 (100 mg/kg per day) decreases the number of seizures per week in a Tsc1GFAP conditional knockout mouse model of epilepsy to a similar extent as PQR530 (Item No. 28563).{58361}

• SKU: CAY26656-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 26656-25
• Package Unit: 25 mg
• Quantity Unit: STK