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Encompassing Amino Acids: 2-173
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Assay Conditions: Assay conditions: enzyme was incubated in 50 mM Tris pH 7.4, 150 mM NaCl, 5 mM DTT, and 12.5 mM PNPP as a substrate for 2 hours at 37°C. Absorbance was read by Tecan spectraphotometer at 405 nm wavelength.
Background: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
Description: Human PRL 3 (GenBank Accession No. NM_032611), a.a. 2-173 with N-terminal His-tag, MW = 19.5 kDa, expressed in an E. coli expression system.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2mM KCl, 20% glycerol, and 3 mM DTT.
Genbank: NM_032611
Storage Stability: >12 months at -80°C
Tags: N-terminal His-tag
Uniprot: O75365
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Dai N. et al., World J. Gastroenterol. 15 (12), 1499-1505 (2009).
2. Radke I. et al., Br. J. Cancer 95 (3), 347-354 (2006).
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